puce-ronde The objectives of the work package are the following:

In order to complete the results obtained on in vitro models, in vivo genotoxicity testing for selected MNs will be performed. Both oral and instillation routes of exposure will be considered.
In vivo genotoxicity data will be obtained mainly from comet and micronucleus tests. Correlation between in vivo and in vitro results will be assessed taking into account the kinetic results.

puce-ronde Work progress

According to the schedule of the Joint Action, the WP6 will begin at month 20 (November 2011). This first year was used for discussions to establish a “state of the art” on how the genotoxicity protocols are usually run in the different laboratories involved and to agree on several points of the protocols. WP6 also follows the work of WP7 in order to consider upcoming concerns and their solutions.

puce-ronde Deliverables:

Characterisation of MNs for their clastogenic/aneugenic effects or DNA damage potentials and correlation analysis.

puce-ronde Work package Leader:  Valerie Fessard from rom French Agency for Food, Environmental and Occupational Health & Safety ( ANSES, France) see WP leader profile picto-pdf

puce-ronde Associated partners working on WP6

Margarita Apostolova from the Institute of Molecular Biology "Roumen Tsenav" ( IMB-BAS, Bulgaria)

Wim de Jong, from the National Institute for Public Health and Environment ( RIVM, The Netherlands)

Laurent Gate from the Institut National de Recherche et de Sécurité ( INRS France)

Fabrice Nesslany from the Insitut Pasteur of Lille ( IPL, France)

Hannu Norppa from Finnish Institute of Occupational Health ( FIOH, Finland)

Maria Joao Silva from the National Health Institute Doutor Ricardo Jorge ( INSA, Portugal)

Maciej Stepnik from the Nofer Institute of Occupational Medicine ( NIOM, Poland)

Hakan Wallin from the National Research Centre for the Working Environment ( NRCWE, Denmark)

Last Updated on Monday, 19 September 2011 15:34