30 July 2010
(i) Strengthening, expanding and sharing the knowledge required for the assessment of the hazard, exposure and overall risk of MNs at the European level. The JA provides a genuine European dimension since it involves a significant number of institutions from many Member States. It will contribute to building a strategy able to generate relevant and reliable data for Public Health authorities to assess the risk of nanomaterials.
(ii) Accelerating the exploitation of existing data (using previous and ongoing EU FP6 and F P7 projects (e.g. NANOSTRAND, NANOSAFE, NANOSH, NANOINTERACT) and the exchange of best practices in risk assessment and management thus minimising the potentially harmful long-term effects of MNs. The JA will thus contribute to giving society alert signals for genotoxic substances. It will constitute the first step towards the creation of a future programme based on long-term animal studies or epidemiological population surveillance by Public Health authorities.
These two objectives above are implicit throughout the whole JA and its 4 scientific work packages.
(iii) Promoting the establishment of robust methodologies throughout the EU. In order to make available a robust methodology (specific and sensitive) to screen potentially genotoxic MNs, fully characterized MNs widely used in consumer products will be tested with standard in vitro assays completed with specific tests. Taking into account these results, a ring test (among the participating Member State laboratories) for the relevant assays will be performed in order to establish a robust methodology to be used by the regulatory control bodies and industries to check for possible genotoxicity using alternative techniques to animal experimentation. In vivo assays will be conducted to characterize the toxicokinetics of selected MNs and compared to in vitro data.Last Updated on Wednesday, 22 September 2010 10:18