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Is the classical micronucleus test (MNT) in vivo in bone marrow a suitable test method?

Up to date, very few studies exist on this assay with MNs. Surprisingly, the in vivo MNT assay has given positive results with some MNs, suggesting possible systemic effects. Therefore, it is worth the effort to see how this assay compares with genotoxicity in target organs. NANOGENOTOX will provide new in vivo data which will shed more light on this question.