It could be interesting to investigate the effects of MNs via ROS (Reactive Oxygen Species) because inflammatory reactions play a substantial role in genotoxic effects.

Identification of oxidative DNA damage is included in the comet assay protocol of some participating laboratories, thus new data will be available on this question, too. Although ROS production and inflammation are considered potential mechanisms for MN genotoxicity, they are not the only potential mechanisms. NANOGENOTOX wanted to assess techniques that could reveal genotoxicity due to various different mechanisms. The association between inflammation and genotoxicity still require a lot of basic research which is not a task of Joint Actions.