The National Health Institute (Istituto Superiore di Sanità, ISS) is the major Italian institution devoted to research in public health and is the leading technical and scientific public body of the Italian National Health Service ( Main activities of the ISS include food safety, environmental health and risk assessment; accordingly, the ISS is partner of several relevant EU Projects. The ISS is a scientific consultant at both national, EU (European Commission, EFSA) and international level (FAO, OECD, WHO) on such topics as food safety, REACH and environment and health as well as new guidelines on toxicological testing. In particular, the ISS is the Italian National Focal Point with the European Food Safety Authority, whose activities are also supported by qualified ISS researchers involved in different panels and WGs. Thus, the ISS acts as an interface between research and risk assessment. The ISS activities include research, control, training and consultancy in the interest of public health protection.

The ISS is active in various fields related to nanotoxicology, from detection, to in vitro/in vivo toxicological testing, to overall risk assessment related to the exposure to nanomaterials. Several departments are implicated in such studies; in particular, the Food and Veterinary Toxicology Unit (Department of Food Safety and Veterinary Public Health) deals with the risk assessment the nanomaterials used in food and contributes directly to NANOGENOTOX.