CEA (French Atomic Energy and Alternative Energies Commission) is a French government-funded organization, leader in research, development and innovation. Its missions cover three main fields: Energy, information and health technologies, and defense and national security. The two following divisions are involved in NANOGENOTOX: Materials Sciences Division through the Saclay Institute of Matter and Radiation (IRAMIS picto-target) and Life Sciences Division through the Institute of biology and technology - Saclay (iBiTec-S picto-target).

At IRAMIS, the Interdisciplinary Laboratory on Molecular Systems and Materials (SIS2M/LIONS picto-target) contributes to WP4 "Physicochemical Characterization of Manufactured Nanomaterials (MNs) and Exposure Mediums (EMs)" This laboratory is specialized in the understanding of structure and properties of nanomaterials by a multidisciplinary approach (chemistry, physico-chemistry, biochemistry, theoretical and experimental physics). More specifically, the team involved in this project will provide thorough characterization of manufactured nanomaterials as raw powders as well as in suspension in suitable media, by means of the following techniques : small and ultra small angle X-ray scattering ( SAXS and USAXS), dynamic light scattering ( DLS), zetametry, and atomic force microscopy ( AFM). The main actors are Olivier SPALLA, a research director who has 20-year experience of fundamental research in physical chemistry of nano-structured materials, oxide nanoparticles stability and interactions in aqueous media, and Camille GUIOT, who recently obtained her Ph.D in colloidal science and is specialized in nanomaterial characterization.

iBiTec-S participates in WP7 "Toxicokinetics and tissue distribution of MNs for specification of organs at risk for genotoxicity testing" through two teams. First, the 14-C labeling laboratory (SCBM/LMC picto-target), supervised by Frédéric TARAN, is specialized in the radiolabeling of biologically active molecules and nanoparticules. In particular, it will take part in the 14-C labeling of carbon nanotubes for biodistribution and pharmacokinetic studies. The second laboratory involved is the Chemistry laboratory for the life Science (SIMOPRO/LCV picto-target), supervised by Vincent DIVE. The core "radioimaging technology" on animal tissue sections enables with unprecedented sensitivity the detection of radiolabeled nanoparticles in animal organs, allowing thus to document the biopersistence of those particles in vivo.

Both laboratories will contribute to the WP7 by examining the in vivo distribution and elimination of the radiolabeled nano-tubes after intravenous injection.

Last Updated on Wednesday, 16 March 2011 15:31