The Universitat Autònoma de Barcelona ( UAB) is a pioneering institution in terms of foreign research. The UAB is clearly oriented towards Europe and the rest of the world, participating as it does in the community initiatives on co-operation, mobility and research, and has established firm links with research centers abroad, especially with those of the European Community.

The Group of Mutagenesis, where this project will be carried out, has very well equipped laboratories to carry out those scientific tasks related to this project including facilities for molecular cytogenetics, cell biology and molecular biology. The Group of Mutagenesis leaded by Professor Marcos was created in 1980 and, since then, it has already participated in 14 EU sponsored projects in the recent years, almost all related with the topic of the human biomonitoring and 澳门足球博彩_2016奥运会外围赌球最新官方网站【赔率最高】 mechanistic aspects of mutagenesis. These participations have permit a wide and molecular cytogenetic methodologies such as FISH, COMET, micronuclei, SCE etc. and has more than 200 international publications in the field of genetic toxicology and related subjects. He has supervised a number of PhD students (27) working in the different research lines of the Group.

One of the recent fields of research included in the group is nanogenotoxicity. Studies in this field included in vitro and in vivo approaches. The in vitro research use different cell lines and the main genetic endpoints are the detection of DNA breakage and

the induction of oxidative damage by means of the comet assay, using specific enzymes detecting oxidized bases. The induction of micronucleus is another biomarker of genotoxicity effects used. To detect the origin of the induced micronuclei fluorescent in situ hybridization techniques are used; thus, chromosome breakage and aneuploidy are detected with this approach. In addition, in vivo approaches using Drosophila are also included. This in vivo approach permits, in addition to genotoxicity, the detection of somatic recombination. Until now, the studies of nanogenotoxicity have been conducted using nanoparticles of silver and cobalt

Contact : Professor Ricard Marcos, Department of Genetics and

Microbiology, Faculty of Biosciences Universitat Autònoma de Barcelona, Campus de Bellaterra, 08193 Cerdanyola del Vallés (Barcelona), Spain.

E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it picto-target, phone: +34935812052, fax: +34935812387

Last Updated on Wednesday, 22 September 2010 10:07