Written by Nanogenotox WP2 | 02 August 2010

The Pasteur Institute of Lille is a centenary research institute founded in 1894 by Louis Pasteur. This private foundation is involved in biomedical research with emphasis on all aspects of public health as it relates to human health and the quality of the environment. The institute conducts basic and applied research in the field of Molecular and Cellular Medicine, including multifactorial diseases (cardiovascular and neurodegenerative diseases, cancer, obesity and diabetes) and infectious and inflammatory pathologies (virology, bacteriology, parasitology, immunology and vaccinology). It also carries out research and development activities in chemical, biological and microbiological analyses of food, water and the environment. The institute is strongly involved in biotechnological development and is open to parnerships with both the private and the public sectors.

Presentation of the Genetic Toxicology Laboratory of IPL

The Genetic Toxicology Laboratory of IPL has extensive experience in genotoxicity studies and offers the core battery of genotoxicity tests in compliance with Good Laboratory Practice regulations ( GLP) and international regulatory guidelines, including OECD, EC, OPPTS and ICH regulatories. These tests comprise gene point mutation tests, chromosomal mutation tests and DNA primary damage tests.

Since 1981, the Genetic Toxicology Laboratory has conducted projects for Human pharmaceutical, chemical, veterinary pharmaceutical, cosmetic, biotechnological, agrochemical, biotech industries and consumer product companies. Our facilities are regularly inspected and Genetic Toxicology Laboratory of IPL is certified by the regulatory authorities/agencies from Europe/ France - AFSSAPS & AFSSA and GIPC.

Concurrently to its contract research activities, the Genetic Toxicology Laboratory of IPL is involved in numerous expertise and research activities including specific research in Nanotoxicology (see below).

List of most relevant experience of the IPL in the field of Nanotoxicology /Genotoxicity of nanoparticles:

Characterization of the determinant physico-chemical properties and establishment of an in vitro model of airway for assessing the genotoxic hazard of nanoparticles from an urban-industrial environment. Project at the regional level, conducted from year 2009 to year 2012 (http://www.nordpasdecalais.fr/sante/appel.asp )

MEGacity Aerosols chemical characterization and TOXicity (MEGATOX Project). With a special attention to the ultra-fine fraction (nanoparticles). Project at the national level (ANR), conducted from year 2009 to year 2012 (http://www.agence-nationale-recherche.fr/documents/aap/2008/selection/ces-2008.pdf )

Contact person

Fabrice Nesslany, Ph.D.

Deputy Head of Toxicology Laboratory

1 rue du professeur Calmette

BP 245 - F - 59019 Lille Cedex

FRANCE

Tel. +33 20 87 72 72 (direct) / 79 14 (general)

Fax. +33 20 87 79 10

Email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

F. NESSLANY was the president of the Working Group Nano3 "Assessment of risks associated with nanomaterials for the general population and the environment" from the French Agency for Environmental and Occupational Health Safety (AFSSET).

Last Updated on Wednesday, 22 September 2010 10:06